New microscope uses adaptable mirror to create clearer images

A new microscope merges different microscopy methods to increase resolution and contrast in thick biological samples. A key component of the method is two-photon microscopy, used to generate a small point of light deep inside the sample. By moving this light throughout the sample and collecting information on how it is being distorted, researchers are able to adjust the shape of the mirror to cancel out the distortions, thus creating a clear image of the whole sample.