Simple, sensitive, and cost-effective assays for analyzing Fragile X-related disorders

Fragile X syndrome, the most common heritable cause of intellectual disability and a frequent cause of autism, is characterized by abnormalities of the FMR1 gene that are difficult to analyze. Preclinical studies of Fragile X and the Fragile X-related disorders are hampered by the lack of low-cost and sensitive yet simple methods. Researchers have now developed a set of assays that are robust, cheap enough for routine research use, and may be suitable for initial patient screening.