Brain stem cell quiescence needs to be actively maintained in Drosophila

Hippo signaling pathway regulates quiescence in the neural stem cells of Drosophila larvae, report scientists. Stem cells are undifferentiated cells able to produce specialized cell types. In the development and growth phases or during regeneration, stem cells provide backup and can generate sizeable amounts of daughter cells. Disruptions to the process can, in turn, result in tumor formation or early depletion of the stem cell reservoir.