Molecular mechanism for generating specific antibody responses to pathogens

Posted by on May 2, 2016 3:16 pm
Categories: health

Follicular helper T cells (Tfh cells), a rare type of T cells, are indispensible for the maturation of antibody-producing B cells. They promote the proliferation of B cells that produce highly selective antibodies against invading pathogens while weeding out those that generate potentially harmful ones. Researchers have now identified a key signal that drives the commitment of immature Tfh cells into fully functional Tfh cells and thus driving the step-by-step process that results in a precisely tailored and effective immune response.

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