Scientists reveal how cell corrects errors made in gene transcription

Posted by on May 3, 2016 5:13 pm
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Categories: health

The dynamics of the RNA polymerase II (Pol II) backtracking process is poorly understood. Scientists have now built a Markov State Model from extensive molecular dynamics simulations to identify metastable intermediate states and the dynamics of backtracking at atomistic detail. The results reveal that Pol II backtracking occurs in a stepwise mode where two intermediate states are involved.

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