Freight train: Myo1c provides cellular transport for protein crucial to kidney filtration

Researchers used small-angle X-ray scattering to determine the full structure of the motor protein Myo1c and its complex with Neph1, a protein crucial for kidney filtration. Their findings suggest that Myo1c uses the actin cytoskeleton as a ‘track’ for Neph1 transport — a finding with translational relevance for glomerular diseases such as diabetic nephropathy, as movement of Neph1 to and from the surface membrane triggers the injury/recovery response.