Rhythm of ‘detox’ and feeding genes in fruitflies, mice coordinated by neuropeptide

A 24-hour rhythm of cellular detoxification in flies and mammals is coordinated by a neuropeptide that also drives feeding in both organisms. Many detoxification genes are expressed with a circadian rhythm in the mouse liver and in the fruitfly equivalent called the fat body. This work could eventually have implications for chronotherapy — the study of the timing of when best to take medications.