‘Piggybacking’ mitochondrial DNA can compromise mitochondrial replacement therapy

Posted by on May 19, 2016 5:01 pm
Categories: health

Mitochondrial replacement therapy shows promise for preventing the inheritance of mitochondrial DNA diseases. However, small amounts of mitochondrial DNA can sometimes hitch a ride with the transferred nucleus, and a new study shows that this DNA can override the mitochondria in the donor cell. The findings may call into question the beneficial effect of nuclear transfer for mitochondrial replacement therapy.

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