Epigenetic modification increases susceptibility to obesity and predicts fatty liver

Scientists have shown in a mouse model that the epigenetic* modification of the Igfbp2 gene observed in the young animal precedes a fatty liver in the adult animal. In addition, young animals with this modification exhibit impaired glucose metabolism and are significantly more prone to morbid obesity. Also in morbidly obese people with incipient diabetes, this modification in the corresponding gene was found. So it may potentially be used as a risk marker.