Topical application of antiretroviral drug combination prevents transmission of (S)HIV

For the first time, researchers show that two powerful antiretroviral drugs can provide complete protection against HIV when delivered topically by a sustained release intravaginal ring (IVR) device. The combination of tenofovir disoproxil fumarate and emtricitabine delivered at independently controlled rates via the pod-IVR was successful at preventing SHIV162p3 infection for over four months.