Regulatory T cells’ involvement in the progress of colon cancer

Researchers have clarified that T-lymphocytes expressing FOXP3 at a low level found in colorectal cancers (CRCs) facilitated cancer immunity. FOXP3 is a master gene of Regulatory T (Treg)  cells that suppress various immune responses including cancer immuity. They found that a certain intestinal bacteria species was involved in the induction of such FOXP3-low T cells enhancing tumor immunity. These findings suggest new potentials in the treatment of CRCs via regulation of intestinal bacteria.