Research helps explain why androgen-deprivation therapy doesn’t work for many prostate cancers
Metastatic prostate cancer, or prostate cancer that has spread to other organs, is incurable. In new research, scientists have identified two gatekeeper genes that allow prostate cancer to progress and resist treatment. Their work illuminates the mechanisms behind lineage plasticity, the ability of prostate cancer to adapt to therapy, and highlights opportunities to disrupt and even reverse this deadly process.
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