Metabolic pathway regulating key stage of embryo development revealed

Posted by on January 17, 2017 2:14 pm
Categories: health

Researchers showed that the mevalonate pathway is essential for embryonic development by promoting primitive streak formation, a key landmark for establishing embryo symmetry and gastrulation. The pathway induces farnesylation of lamin-B, which is implicated in inducing expression of primitive streak genes. The findings expand understanding of how embryos transition from a featureless ball of cells into a hollow, three-layered gastrula.

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