Putting the ‘squeeze’ on drug delivery

One big challenge targeted drug delivery faces today is efficiently “loading” a drug into a carrier without compromising the carrier’s structural integrity. A promising method is to deform a carrier by squeezing it through a narrow, microscale constriction. This mechanical deformation creates transient pores in the carrier membrane to enhance the membrane’s permeability to macromolecules and promote the efficient uptake of drugs. Scientists are now developing a model for vesicle squeezing that can be used to predict and optimize drug loading procedures.