Type 2 diabetes: It all starts in the liver

Among the detrimental effects of obesity is the risk of developing type 2 diabetes. If the strong links between obesity and type 2 diabetes are well known, the cellular and molecular mechanisms were so far poorly understood. Scientists unravel the factors linking obesity and insulin resistance. By deciphering how the protein PTPR-? inhibits insulin receptors located at the surface of liver cells, they open door to potential news therapeutic strategies.