Nuclear DNA gets cut, activates immune system to attack cancer cells

The enzyme MUS81 cuts DNA in the nucleus of cancer cells, causing the cut DNA to move to the cytoplasm instead of becoming degraded. The out-of-place DNA triggers an immune response against cancer cells. Discovering this new means of enhancing anti-cancer immune responses could lead to more effective cancer therapies using a combination of a MUS81-stimulating drug and an immunotherapy.